NEUTROPHIL/LYMPHOCYTE AND PLATELET/LYMPHOCYTE RATIO IN PATIENTS WITH CELIAC

Abstract

Background and Aim: Celiac disease is a chronic inflammatory small intestine enteropathy triggered by dietary gluten in people with genetic predisposition. In this study; It was aimed to reveal the relationship between neutrophil-lymphocyte ratio and platelet-lymphocyte ratio and celiac disease, which is a systemic inflammatory disease, and to compare these values with Marsh score. Materials and Methods: 132 patients diagnosed with celiac disease and 55 healthy controls were included in the study. The results of the patients and the control group were scanned retrospectively from the hospital automation system and patient files, and statistical analysis was performed. In addition, the data obtained with the march scores in the pathology reports of the previous biopsies were compared. Results: While 60.0% of celiac patients had low iron, 63.3% ferritin, 78.0% vitamin D, 30.0% folate, 51.8% iron binding was found to be high. Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio were significantly higher in the patient group compared to the control group (p: 0.000, p: 0.002, respectively). In the ROC analysis, the area under the curve was 0.708 for HGB, 0.687 for PLT, 0.674 for RDW, 0.606 for neutrophil, 0.706 for neutrophil-lymphocyte ratio, and 0.644 for platelet-lymphocyte ratio. Conclusion: In conclusion, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio are widely used cheap tests that can be calculated by complete blood count. Both the neutrophil-lymphocyte ratio and the platelet-lymphocyte ratio can be used in celiac disease as an important measure of systemic inflammation.