THE POSITION OF PLATELET MASS INDEX IN DIAGNOSIS IN ACUTE CORONARY SYNDROME PATIENTS ADMITTING TO THE EMERGENCY DEPARTMENT
Abstract views: 302
/ 
PDF downloads: 126
DOI:
https://doi.org/10.55433/gsbd/213Keywords:
Emergency Medicine, Acute Coronary Syndrome, Chest PainAbstract
Acute coronary syndrome (ACS) describes ischemia and/or infarction situations that occur as a result of sudden decrease in coronary blood flow. In this study, we aimed to investigate the place of the platelet mass index (TKI) value, a new parameter, in the differential diagnosis of cardiac and non-cardiac chest pain in patients presenting to the emergency department with chest pain. In the study, pre-treatment biochemistry, hemogram markers, and electrocardiography (ECG) results of a total of 450 adult patients over the age of 18 who applied to the emergency department of the University of Health Sciences Mehmet Akif İnan Training and Research Hospital with complaints of chest pain between January 2020 and January 2022 were examined. The average age of the patient group was 58,070 (34-78) and there were 224 men and 226 women. It was observed that the platelet mass index value was statistically significant (p<0.001) between the cardiac chest pain group and the non-cardiac chest pain groups. It has been observed that some biochemical markers such as red blood cell width (RDW), MPV (Mean Platelet Volume) and platelet, among the hemogram parameters, have high diagnostic values in diseases such as acute myocardial infarction, renal artery stenosis, diabetes mellitus, hypertension and hyperlipidemia. In our study, it was determined that the MPV values of the patient group diagnosed with ACS (STEMI and NSTEMI) were statistically significant compared to the patient group without cardiac chest pain. It was determined that the platelet count was significant between the STEMI patient group and the non-cardiac chest pain patient group (p<0.001). It was observed that there was no significant difference between the STEMI and NSTEMI patient groups, which are the ACS groups (p = 1).
References
Amsterdam, E.A., et al., 2014 AHA/ACC guideline for the management of patients with non–ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2014. 64(24): p. e139-e228.
Thygesen, K., et al., Fourth universal definition of myocardial infarction (2018). 2018. 138(20): p. e618-e651.
McManus, D.D., et al., Recent trends in the incidence, treatment, and outcomes of patients with STEMI and NSTEMI. 2011. 124(1): p. 40-47.
Thygesen, K., et al., Task Force for the Universal Definition of Myocardial Infarction. Third universal definition of myocardial infarction. 2012. 9(11): p. 620-633.
Frąk, W., et al., Pathophysiology of Cardiovascular Diseases: New Insights into Molecular Mechanisms of Atherosclerosis, Arterial Hypertension, and Coronary Artery Disease. 2022. 10(8): p. 1938.
Makki, N., T.M. Brennan, and S.J.J.o.i.c.m. Girotra, Acute coronary syndrome. 2015. 30(4): p. 186-200.
Thompson, C.B., et al., Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. 1982. 50(3): p. 509-519.
Corash, L., H. Tan, and H.R. Gralnick, Heterogeneity of human whole blood platelet subpopulations. I. Relationship between buoyant density, cell volume, and ultrastructure. 1977.
Khaspekova, S., et al., Mean platelet volume: interactions with platelet aggregation activity and glycoprotein IIb-IIIa and Ib expression levels. 2014. 60(1): p. 94-108.
May, J.E., et al., Three neglected numbers in the CBC: The RDW, MPV, and NRBC count. 2019. 86(3): p. 167-172.
Hoffman, M., et al., Leukocytes and coronary heart disease. 2004. 172(1): p. 1-6.
Zdzienicka, J., et al., Original article Patients with non-ST-elevation myocardial infarction and without chest pain are treated less aggressively and experience higher in-hospital mortality. 2007. 65(7): p. 769-775.
Eken, C., et al., Acil Servise Göğüs Ağrısı ile Başvuran Hastalarda Olasılık Sınıflaması. 2006. 6(1): p. 041-048.
Dai, D.-F., et al., Joint effects of N-terminal pro-B-type-natriuretic peptide and C-reactive protein vs angiographic severity in predicting major adverse cardiovascular events and clinical restenosis after coronary angioplasty in patients with stable coronary artery disease. 2008. 72(8): p. 1316-1323.
Perlstein, T.S., et al., Red blood cell distribution width and mortality risk in a community-based prospective cohort. 2009. 169(6): p. 588-594.
Chang, H.-Y., et al., Impact of platelet volume on the clinical outcomes of patients with acute coronary syndrome. 2019. 35(6): p. 563.
Dehghani, M.R., et al., Diagnostic importance of admission platelet volume indices in patients with acute chest pain suggesting acute coronary syndrome. 2014. 66(6): p. 622-628.
Karaman, S. and A.J.E.M.I. Coskun, Do MCHC, MPV, and procalcitonin levels determine prognosis in acute coronary syndrome? 2019. 2019.
Karakayali, O., et al., Role Of MPV And Platelet/MPV Ratio İn The Diagnosis Of Cardiac Dilemma; Cardiac Or Non-Cardiac Chest Pain, And Severity Of Acute Coronary Syndrome. 2019. 8(2): p. 182-190.
Ilhan, O. and M.J.P.I. Bor, Platelet mass index and prediction of severity of transient tachypnea of the newborn. 2019. 61(7): p. 697-705.
Nowak, M., J. Kornhuber, and R.J.S. Meyrer, Daytime impairment and neurodegeneration in OSAS. 2006. 29(12): p. 1521-1530.
Thachil, J. Platelets in inflammatory disorders: a pathophysiological and clinical perspective. in Seminars in Thrombosis and Hemostasis. 2015. Thieme Medical Publishers.
Vagdatli, E., et al., Platelet distribution width: a simple, practical and specific marker of activation of coagulation. 2010. 14(1): p. 28.
Boshnak, N., M. Boshnaq, and H.J.J.o.I.S. Elgohary, Evaluation of platelet indices and red cell distribution width as new biomarkers for the diagnosis of acute appendicitis. 2018. 31(2): p. 121-129.
Berny‐Lang, M.A., et al., Do immature platelet levels in chest pain patients presenting to the emergency department aid in the diagnosis of acute coronary syndrome? 2015. 37(1): p. 112-119.
Downloads
Published
Versions
- 2024-07-02 (2)
- 2023-09-27 (1)
How to Cite
Issue
Section
License
Copyright (c) 2023 Göbeklitepe Sağlık Bilimleri Dergisi
This work is licensed under a Creative Commons Attribution 4.0 International License.
The journal is licensed under a 