INVESTIGATION OF THE EFFECTS OF DIFFERENT LIPID SOLUTIONS USED IN NEONATAL INTENSIVE CARE UNIT ON MORBIDITIES AND OXIDANT-ANTIOXIDANT SYSTEMS OF PREMATURE BABIES

Abstract

To investigate the effects of using SmofLipid and IntraLipid solutions in total parenteral nutrition of premature babies on their morbidities and oxidant-antioxidant systems. This randomized, controlled, single-blind prospective study was conducted in Zekai Tahir Burak Gynaecology Training and Research Hospital. The babies received either SMOFlipid (n=33) or Intralipid (n=32). With the samples taken at baseline and at day 7 of lipid infusion, the laboratory tests and the total antioxidant capacity (TAC), total oxidant capacity (TOC) and oxidative stress index (OSI: TAC/TOC/100) were studied. Parenteral nutrition support was provided to both groups for at least 7 days. While no statistically significant differences were found between the observed values and expected values in most of the demographic characteristics studied (p>0.05), a statistically significant difference was found between the observed values and expected values of the length of CPAP and length of hospitalization (p<0.05). No statistically significant difference was found between the observed values and expected values with respect to morbidities between the two groups. A week later, an increase in the TAC values and a decrease in the TOC and OSI values were observed in both groups, and the results were found no statistically difference between them (p>0.05). Similar oxidative stress conditions were found after giving SMOFlipid and IntraLipid solutions and no statistically significant difference was found in morbidity rates.