INVESTIGATION OF THE EFFECTS OF DIFFERENT LIPID SOLUTIONS USED IN NEONATAL INTENSIVE CARE UNIT ON MORBIDITIES AND OXIDANT-ANTIOXIDANT SYSTEMS OF PREMATURE BABIES
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Keywords:Parenteral nutrition, Total, lipid emultion, premature birth, oxidative stress
To investigate the effects of using SmofLipid and IntraLipid solutions in total parenteral nutrition of premature babies on their morbidities and oxidant-antioxidant systems. This randomized, controlled, single-blind prospective study was conducted in Zekai Tahir Burak Gynaecology Training and Research Hospital. The babies received either SMOFlipid (n=33) or Intralipid (n=32). With the samples taken at baseline and at day 7 of lipid infusion, the laboratory tests and the total antioxidant capacity (TAC), total oxidant capacity (TOC) and oxidative stress index (OSI: TAC/TOC/100) were studied. Parenteral nutrition support was provided to both groups for at least 7 days. While no statistically significant differences were found between the observed values and expected values in most of the demographic characteristics studied (p>0.05), a statistically significant difference was found between the observed values and expected values of the length of CPAP and length of hospitalization (p<0.05). No statistically significant difference was found between the observed values and expected values with respect to morbidities between the two groups. A week later, an increase in the TAC values and a decrease in the TOC and OSI values were observed in both groups, and the results were found no statistically difference between them (p>0.05). Similar oxidative stress conditions were found after giving SMOFlipid and IntraLipid solutions and no statistically significant difference was found in morbidity rates.
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