ÇİNKO FİTALOSİYANİN-1’İN SARS COV-2 MPRO’DA MOLEKÜLER DOCKİNG YÖNTEMİYLE ARAŞTIRILMASI: İN SİLİCO ÇALIŞMA


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Authors

  • Erkan ÖNER Mersin Üniversitesi, Sağlık Bilimler Enstitüsü, Eczacılık Fakültesi Biyokimya Bölümü
  • İlter DEMİRHAN Harran Üniversitesi, SHMYO, Biyomedikal Cihaz Teknolojisi Programı
  • Seda İKİKARDEŞ Kahramanmaraş Sütçü İmam Üniversitesi, Fen Bilimleri Enstitüsü, Biyomühendislik Bölümü
  • Ergül Belge KURUTAŞ Kahramanmaraş Sütçü İmam Üniversitesi, Sağlık Bilimleri Enstitüsü, Tıbbi Biyokimya Bölümü
  • Serap YALIN Mersin Üniversitesi, Sağlık Bilimleri Enstitüsü, Eczacılık Fakültesi Biyokimya Bölümü

DOI:

https://doi.org/10.55433/gsbd.266

Keywords:

Sars-Cov-2 Main Protease, Molecular Docking, Zinc Phthalocyanine

Abstract

The coronavirus disease has caused the death of many people in the world and in our country. This unexpected negative health terror has left countries in a difficult situation. In this study, it was aimed to investigate Zinc Phthalocyanine-1 (Zn-Pc-1) against SARS-CoV-2 main protease (MPro) by in silico method. In our research, Zn-Pc-1 was enabled to target the active site of the SARS-CoV-2 MPro receptor with PDB ID:6LU7. Molecular docking study was done with Autodock program. The result of molecular docking was found to be -10.6 kcal/mol. The results obtained from the study showed that Zn-Pc-1 has a very high potential to be an inhibitor of SARS CoV-2 MPro.Key Words: Sars-Cov-2 Main Protease, Molecular Docking, Zinc Phthalocyanine

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Published

2022-09-30

How to Cite

ÖNER, E., DEMİRHAN, İlter, İKİKARDEŞ, S., KURUTAŞ, E. B., & YALIN, S. (2022). ÇİNKO FİTALOSİYANİN-1’İN SARS COV-2 MPRO’DA MOLEKÜLER DOCKİNG YÖNTEMİYLE ARAŞTIRILMASI: İN SİLİCO ÇALIŞMA. Göbeklitepe Sağlık Bilimleri Dergisi, 5(9), 71–76. https://doi.org/10.55433/gsbd.266

Issue

Vol. 5 No. 9 (2022)

Section

Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.